My first week was challenging. First lecture of 2017, I was unable to attend (tube strike) and as I live quite a bit away from university the trek down would have taken longer than the lecture (1 hour), but luckily I got my hands on recordings of the lecture and should be able to catch up just fine. Tuesday. I missed 3 hours of a lecture. I’m seriously painting myself as a ‘horrible’ student. I’m not, there were just some unforeseeable circumstances that prevented me from going but LUCIKLY, the lecture was Q-reviewed and I am now watching the lecture back and making notes. Next lecture, I made it in. Basic Immunology. I absolutely loved it, I was able to follow the lecturer throughout and understand the basic concepts, it was more of a consolidating lecture as he spoke about the primary lymphoid tissue, secondary lymphoid tissue, T cells and B cells, bone marrow, thymus, lymphocyte development, the usual you would expect of a first lecture that ‘eases’ you in. And lastly clinical microbiology.
Monday – Biochemistry
Tuesday – Pharmacology
Wednesday – Immunology
Thursday – Clinical Microbiology
+ Labs, Workshops, and Case study (essay/MCQ)
First lecture was about Glutamate Dehydrogenase (GDH) activity and regulation. Glutamate Dehydrogenase is an enzyme that partakes in amino acid degradation, a metabolic process that mainly takes place in the liver; although GDH is highly expressed in the brain, pancreas, and kidney. GDH catalyses the conversion of an amino acid into a a-ketoacid (deamination) as well as the conversion of an a-ketoacid back to an amino acid (amination). This is a reversible transamination reaction; whereby GDH – a transaminase enzyme acts to remove the a-amino group from a-amino acid (i.e. glutamate) to form a-ketoacid. GDH deamination is an anaplerotic reaction as an intermediate (a-ketoacid) formed can be used in the Krebs, TCA cycle to provide energy. Anaplerotic reactions are carried out when energy is low and there is no requirement for growth and metabolic top-up.
What is the difference between pharmacokinetics and pharmacodynamics?
Pharmacokinetics – the effect the body has on the drug (i.e. the breakdown of drugs by the liver). Defined as the measurement of changes in drug concentration, with time in different locations of the body – what the body does to the drug
Pharmacodynamics – the effect of the drug on the body. This would include events brought about by interactions of the drug with its receptor/primary site of action. It is the relationship between drug concentration at the site of action and resulting effect – what the drug does to the body.
Terminology to know: pharmacodynamics, pharmacokinetics, agonist, antagonist, occupancy, affinity, efficacy, and potency.
Toll-like receptors; TLR are activated by a number of different pathogen associated molecular patterns (PAMPS). PAMPs are characteristic components of the pathogen found at either one or more stages of infection, but absent in the vertebrae cell (i.e. the flagellum found on bacterial cells). This allows differentiation between self and non-self components. TLRs are found on the surface of mammalian cells and act to recognise components of the pathogen; bacterial/virus/fungi in order to alert the immune system. There are 10 expressed TLR gene in humans (so 10 TLRs present, what are they?)
PAMPs that can be detected (examples):
- CpG DNA
- Double-stranded viral DNA
- Lipopolysaccharide (gram-negative)
Don’t judge me, I’m yet to start on clinical microbiology.
That was my first week. It’s been a month now. I have been struggling a bit, trying to adjust to the added workload from Sem B has been quite challenging. The detail of information you’re required to know is in fact more, and there is more to know. I know Medicine is x100 worse and the lectures they get in a day is probably a week’s worth of mine (slight exaggeration but could be true). So I have no excuse, I really need to step up and catch up with my notes; hence I am patiently waiting for reading week.
I’ve started reading: The Power of Habit by Charles Duhigg
Just to gain the concept of making good habits and changing bad ones.
I’d really like to make a habit of waking up early in the morning and dwelling in the presence of God before going to university and getting by through the day. I would like to make a habit of being more consistent with my studies despite the long commutes, to be consistent with the gym, as well as this blog. The book I’m reading is not going to suddenly form new habits for me, I’d much prefer the needed insight on what to do to make changes. It won’t be instant – but it’s a step in the right direction. In all honesty, I know my helper is God. And through Christ who strengthens me, I can do anything. My God will help me form the right habits, and see me through the plan and purpose he has for me.
1 Thessalonians 5:24 He who calls you is faithful; he will surely do it (ESV)
2 Peter 1:5-8 For this very reason, make every effort to supplement your faith with virtue, and virtue with knowledge, 6 and knowledge with self-control, and self-control with steadfastness, and steadfastness with godliness, 7 and godliness with brotherly affection, and brotherly affection with love. 8For if these qualities are yours and are increasing, they keep you from being ineffective or unfruitful in the knowledge of our Lord Jesus Christ. (ESV)